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Arvinas, Inc. (ARVN)

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Previous Close77.51
Open76.79
Bid0.00 x 900
Ask0.00 x 1100
Day's Range74.86 - 78.32
52 Week Range19.68 - 92.77
Volume433,148
Avg. Volume1,180,810
Market Cap3.682B
Beta (5Y Monthly)2.19
PE Ratio (TTM)N/A
EPS (TTM)-3.02
Earnings DateApr 26, 2021 - Apr 30, 2021
Forward Dividend & YieldN/A (N/A)
Ex-Dividend DateN/A
1y Target Est103.00
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  • Arvinas, Inc. (ARVN) Reports Q4 Loss, Misses Revenue Estimates
    Zacks

    Arvinas, Inc. (ARVN) Reports Q4 Loss, Misses Revenue Estimates

    Arvinas, Inc. (ARVN) delivered earnings and revenue surprises of -26.92% and -70.27%, respectively, for the quarter ended December 2020. Do the numbers hold clues to what lies ahead for the stock?

  • Benzinga

    Arvinas: Q4 Earnings Insights

    Shares of Arvinas (NASDAQ:ARVN) remained unaffected after the company reported Q4 results. Quarterly Results Earnings per share decreased 76.79% year over year to ($0.99), which missed the estimate of ($0.78). Revenue of $2,218,000 decreased by 54.67% year over year, which missed the estimate of $6,910,000. Outlook Earnings guidance hasn't been issued by the company for now. View more earnings on ARVN Arvinas hasn't issued any revenue guidance for the time being. Recent Stock Performance 52-week high: $92.77 52-week low: $19.68 Price action over last quarter: Up 256.56% Company Profile Arvinas Inc is a United States-based private biopharmaceutical company focused on developing first-in-class protein degradation therapeutics for cancers and other difficult-to-treat diseases. The company's proprietary Proteolysis-Targeting Chimera (PROTAC), work by inducing the cell's own ubiquitin-proteasome system to target, degrade and remove disease-causing proteins. Its pipeline candidates include metastatic castration-resistant prostate cancer, metastatic ER-breast cancer, additional oncology indications, tauopathies, and other neurodegenerative diseases. See more from BenzingaClick here for options trades from BenzingaRecap: Biohaven Pharmaceutical Q4 EarningsSuperior Group: Q4 Earnings Insights© 2021 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.

  • Arvinas Reports Fourth Quarter and Full Year 2020 Financial Results and Provides Corporate Update
    GlobeNewswire

    Arvinas Reports Fourth Quarter and Full Year 2020 Financial Results and Provides Corporate Update

    NEW HAVEN, Conn., March 01, 2021 (GLOBE NEWSWIRE) -- Arvinas, Inc. (Nasdaq: ARVN), a clinical-stage biopharmaceutical company creating a new class of drugs based on targeted protein degradation, today reported financial results for the fourth quarter and full year ended December 31, 2020 and provided a corporate update. “2020 was a breakthrough year for Arvinas and for the patients we aim to serve, as we reported clear signals of efficacy in both of our clinical-stage programs. These data provided further validation that our approach to protein degradation could potentially change the lives of patients with few or no therapeutic options,” said John Houston, Ph.D., Chief Executive Officer at Arvinas. “Despite the unprecedented circumstances of a pandemic, our clinical trials and preclinical research continued to deliver, and we enter 2021 well positioned to extend our success and progress our programs in oncology and neurodegeneration.” Business Highlights and Recent Developments Presented interim Phase 1 data for ARV-471 showing potential for best-in-class safety and tolerability, estrogen receptor (ER) degradation greater than that previously reported for the current standard of care agent (fulvestrant), and a robust efficacy signal in heavily pretreated patients with locally advanced or metastatic ER positive / HER2 negative (ER+/HER2-) breast cancerPresented data from the ongoing dose escalation portion of the Phase 1/2 trial of ARV-110 in men with metastatic castration-resistant prostate cancer (mCRPC), providing additional evidence of anti-tumor activity and patient benefit, including a prostate specific antigen reduction ≥50% (PSA50) in 2 of 5 (40%) in a molecularly defined patient populationClosed an underwritten public offering of 6,571,428 shares of common stock at a public offering price of $70.00 per share, including the exercise in full by the underwriters of their option to purchase additional shares of common stock. Arvinas received net proceeds of $431.9 million, after deducting underwriting discounts and commissions and offering expensesInitiated the ARDENT Phase 2 dose expansion study of ARV-110 (Dose: 420 mg daily)Initiated the VERITAC Phase 2 dose expansion study of ARV-471 (Dose: 200 mg daily)Initiated a Phase 1b trial of ARV-471 in combination with Ibrance® (palbociclib) Anticipated Milestones and Expectations ARV-471 Completion of the Phase 1 dose escalation (1H21)Presentation of completed Phase 1 dose escalation data (2H21)Announcement of safety data from the Phase 1b trial in combination with Ibrance® (palbociclib) (2H21)Initiation of a window of opportunity study in adjuvant breast cancer (2H21)Initiation of a combination trial of ARV-471 and another targeted therapy in 2L/3L metastatic breast cancer (2H21) ARV-110 Completion of the Phase 1 dose escalation (1H21)Presentation of completed Phase 1 dose escalation data (2H21)Announcement of interim data from the ARDENT Phase 2 dose expansion at 420 mg (2H21)Initiation of combination trial(s) with standards-of-care (2021) Other Clinical Milestones Initiation of first-in-human study of ARV-766, an androgen receptor (AR) degrader with a differentiated profile from ARV-110, in patients with metastatic castration-resistant prostate cancer (1H21) Financial Guidance Based on its current operating plan, Arvinas expects its cash, cash equivalents, and marketable securities will be sufficient to fund its planned operating expenses and capital expenditures into 2024. Full Year and Fourth Quarter Financial Results Cash, Cash Equivalents and Marketable Securities Position: As of December 31, 2020, cash, cash equivalents and marketable securities were $688.5 million as compared with $280.9 million as of December 31, 2019. The increase primarily related to net proceeds from the issuance of common stock and proceeds from the exercise of stock options of $504.7 million, proceeds from two collaborators of $7.4 million, partially offset by cash used to fund operations of approximately $98.1 million and cash used to purchase fixed assets and leasehold improvements of $6.4 million. Research and Development Expenses: Research and development expenses were $108.4 million and $33.2 million for the year and quarter ended December 31, 2020, respectively, as compared with $67.2 million and $20.4 million for the year and quarter ended December 31, 2019, respectively. The increase in research and development expenses for the year of $41.2 million primarily related to Arvinas’ continued investment in its wholly owned platform, exploratory and lead optimization programs of $17.6 million, its androgen receptor (AR) program of $12.3 million and estrogen receptor program (ER) of $11.3 million. The increase in research and development expense for the quarter of $12.8 million primarily related to Arvinas’ continued investment in its wholly owned platform, exploratory and lead optimization programs of $5.1 million, its AR program of $4.8 million and ER program of $2.9 million. General and Administrative Expenses: General and administrative expenses were $38.3 million and $12.2 million for the year and quarter ended December 31, 2020, respectively, as compared with $27.3 million and $7.3 million for the year and quarter ended December 31, 2019, respectively. The increase in general and administrative expenses for the year of $11.0 million related to an increase of $9.6 million in personnel and facility related costs, including $4.8 million related to stock compensation expense, and insurance, taxes and professional fees of $1.4 million. The increase in general and administrative expenses for the quarter of $5.0 million primarily related to an increase of $2.9 in personnel and facility cost, including $1.4 million related to stock compensation expense and $1.7 million of legal and other professional services. Revenues: Revenues were $21.8 million and $2.2 million for the year and quarter ended December 31, 2020, respectively, as compared with $43.0 million and $4.9 million for the year and quarter ended December 31, 2019, respectively. Revenue for the year ended December 31, 2019 included $24.7 million of revenue recognized from the Arvinas contribution of the license to the joint venture between Bayer and Arvinas to pursue the PROTAC® technology in agricultural applications (the Joint Venture). The remaining collaboration revenue of $18.3 million and revenue of $4.9 million for the year and quarter ended December 31, 2019, respectively, was generated from the license and rights to technology fees and research and development activities related to the collaboration and license agreement with Bayer that was initiated in July 2019, the collaboration and license agreement with Pfizer that was initiated in January 2018, and the amended and restated option, license and collaboration agreement with Genentech that was initiated in November 2017. The increase in collaboration revenue of $3.5 million for the year was primarily related to the Bayer agreement having only a partial year of revenue recognized in 2019 and an increase in activities related to the Pfizer agreement. The decrease in collaboration revenue of $2.7 million in the quarter primarily related to a collaborator adding new targets that extended the period of revenue recognition for the collaboration agreement. Loss from Equity Method Investment: Loss from equity method investment for the year ended December 31, 2019 was $24.7 million, which related to the loss from the equity method investment in the Joint Venture. The loss was generated from the Joint Venture’s expensing the values associated with the contributed intellectual property from the Joint Venture partners. Net Loss: Net loss was $119.3 million and $41.5 million for the year and quarter ended December 31, 2020, respectively, as compared with $70.3 million and $21.0 million for the year and quarter ended December 31, 2019, respectively. The increase in net loss for the year and quarter ended December 31, 2020 of $49.0 million and $20.5 million, respectively, primarily related to Arvinas’ continued investment in its platform, exploratory and lead optimization programs, its AR program, its ER program, and an increase in general and administrative infrastructure costs. About ARV-110ARV-110 is an investigational orally bioavailable PROTAC® protein degrader designed to selectively target and degrade the androgen receptor (AR). ARV-110 is being developed as a potential treatment for men with metastatic castration-resistant prostate cancer. ARV-110 has demonstrated activity in preclinical models of AR mutation or overexpression, both common mechanisms of resistance to currently available AR-targeted therapies. About ARV-471ARV-471 is an investigational orally bioavailable PROTAC® protein degrader designed to specifically target and degrade the estrogen receptor (ER) for the treatment of patients with locally advanced or metastatic ER+/HER2- breast cancer. In preclinical studies, ARV-471 demonstrated near-complete ER degradation in tumor cells, induced robust tumor shrinkage when dosed as a single agent in multiple ER-driven xenograft models, and showed superior anti-tumor activity when compared to a standard of care agent, fulvestrant, both as a single agent and in combination with a CDK4/6 inhibitor. About ArvinasArvinas is a clinical-stage biopharmaceutical company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its proprietary PROTAC® Discovery Engine platform to engineer proteolysis targeting chimeras, or PROTAC® targeted protein degraders, that are designed to harness the body’s own natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins. In addition to its robust preclinical pipeline of PROTAC® protein degraders against validated and “undruggable” targets, the company has two clinical-stage programs: ARV-110 for the treatment of men with metastatic castrate-resistant prostate cancer; and ARV-471 for the treatment of patients with locally advanced or metastatic ER+/HER2- breast cancer. For more information, visit www.arvinas.com. Forward-Looking StatementsThis press release contains forward-looking statements that involve substantial risks and uncertainties, including statements regarding the development and regulatory status of our product candidates, including the timing of initiation or completion of or availability of data from our clinical trials for ARV-110 and ARV-471, the potential advantages and therapeutic potential of our product candidates and the sufficiency of cash resources. All statements, other than statements of historical facts, contained in this press release, including statements regarding our strategy, future operations, prospects, plans and objectives of management, are forward-looking statements. The words “anticipate,” “believe,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “predict,” “project,” “target,” “potential,” “will,” “would,” “could,” “should,” “continue,” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. We may not actually achieve the plans, intentions or expectations disclosed in our forward-looking statements, and you should not place undue reliance on our forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in the forward-looking statements we make as a result of various risks and uncertainties, including but not limited to: whether we will be able to successfully conduct Phase 1/2 clinical trials for ARV-110 and ARV-471, conduct a Phase 1 clinical trial of ARV-766 complete our clinical trials for our other product candidates, and receive results from our clinical trials on our expected timelines, or at all, whether our cash resources will be sufficient to fund our foreseeable and unforeseeable operating expenses and capital expenditure requirements on our expected timeline and other important factors discussed in the “Risk Factors” sections contained in our quarterly and annual reports on file with the Securities and Exchange Commission. The forward-looking statements contained in this press release reflect our current views with respect to future events, and we assume no obligation to update any forward-looking statements except as required by applicable law. These forward-looking statements should not be relied upon as representing our views as of any date subsequent to the date of this release. Contacts for Arvinas InvestorsWill O’Connor, Stern Investor Relations ir@arvinas.com MediaKirsten Owens, Arvinas Communicationskirsten.owens@arvinas.com Arvinas, Inc.Consolidated Statement of Operations (Unaudited) Quarter Ended December 31, Year Ended December 31, 2020 2019 2020 2019 Revenue$2,217,692 $4,893,273 $21,801,777 $42,976,478 Operating expenses: Research and development 33,200,159 20,414,783 108,355,853 67,193,830 General and administrative 12,230,997 7,268,390 38,303,401 27,307,162 Total operating expenses 45,431,156 27,683,173 146,659,254 94,500,992 Loss from operations (43,213,464) (22,789,900) (124,857,477) (51,524,514)Interest and other income 1,666,976 1,742,184 5,525,413 5,907,287 Loss from equity method investment — — — (24,675,000)Net loss (41,546,488) (21,047,716) (119,332,064) (70,292,227)Net loss per common share, basic and diluted (0.99)$(0.56) (3.02) (2.13)Weighted average common shares outstanding, basic and diluted 41,767,980 37,338,484 39,534,497 32,927,697 Arvinas, Inc.Consolidated Balance Sheet (Unaudited) December 31, 2020 2019 Assets Current assets: Cash and cash equivalents$588,373,232 $9,211,057 Marketable securities 100,157,618 271,661,456 Account receivable 1,000,000 — Other receivables 7,443,654 6,280,828 Prepaid expenses and other current assets 6,113,122 3,727,294 Total current assets 703,087,626 290,880,635 Property, equipment and leasehold improvements, net 12,259,515 8,455,411 Operating lease right of use assets 1,992,669 2,278,623 Other assets 28,777 26,757 Total assets$717,368,587 $301,641,426 Liabilities and stockholders' equity Current liabilities: Accounts payable$7,121,879 $4,556,827 Accrued expenses 18,859,840 7,602,904 Deferred revenue 22,150,861 19,979,525 Current portion of operating lease liabilities 952,840 673,896 Total current liabilities 49,085,420 32,813,152 Deferred revenue 22,938,233 38,427,882 Long term debt, net of current portion 2,000,000 2,000,000 Operating lease liabilities 1,087,422 1,714,111 Total liabilities 75,111,075 74,955,145 Commitments and contingencies Stockholders' equity: Common stock, $0.001 par value, 48,455,741 and 38,461,353 shares issued and outstanding as of December 31, 2020 and 2019, respectively 48,455 38,461 Accumulated deficit (491,888,910) (372,556,846)Additional paid-in capital 1,133,537,171 599,097,090 Accumulated other comprehensive income 560,796 107,576 Total stockholders' equity 642,257,512 226,686,281 Total liabilities and stockholders' equity$717,368,587 $301,641,426