|Bid||101.96 x 1200|
|Ask||102.78 x 1200|
|Day's Range||101.49 - 103.44|
|52 Week Range||89.01 - 116.25|
|PE Ratio (TTM)||21.09|
|YTD Daily Total Return||6.63%|
|Beta (3Y Monthly)||1.36|
|Expense Ratio (net)||0.47%|
It's time to get technical at the YFi Interactive touch screen. Joining Yahoo Finance's Myles Udland is Jared Blikre to break down the week's price action in stocks and bonds.
Shares of Hepion Pharmaceuticals Inc. soared 45% in very active premarket trading Thursday, after the biopharmaceutical company published data showing potential for its CRV431 to be a drug candidate for liver disease treatment. Trading volume swelled to 1.5 million shares, enough to make Hepion's stock the most actively traded ahead of the open, and about 14-times the full-day average of about 110,000 shares. The company said CRV431 inhibited all cyclophilin isoforms tested, suggesting it could be used to target multiple disease mechanisms in the liver. "We believe that targeting these pathways is necessary for optimal treatment of chronic liver diseases including NASH, cancer, and viral hepatitis," said Hepion Chief Executive Robert Foster. "Further, we believe that CRV431's pan-cyclophilin inhibition is well-suited to address multiple therapeutic needs that are currently either underserved, or completely absent." The stock has tumbled 31.5% over the past three months through Wednesday, while the iShares Nasdaq Biotechnology ETF has slipped 3.1% and the S&P 500 has gained 0.2%.
Shares of Achillion Pharmaceuticals Inc. rocketed 82% in premarket trading Wednesday, after the biopharmaceutical company agreed to be acquired by Alexion Pharmaceuticals Inc. in a cash deal valued at $930 million. Alexion's stock slipped 0.1% ahead of the open. Under terms of the deal, Alexion will pay $6.30 for each Achillion share outstanding, which is 73% above Tuesday's closing price of $3.65 and implies a market-capitalization of $880.05 million. The deal also includes potential for an additional payment for Achillion shares in the form of contingent value rights (CVRs) to be paid if certain clinical and regulatory milestones are achieved. The CVRs include $1 a share for U.S. Food and Drug Administration approval of danicopan and $1 a share for ACH-5228 phase 3 initiation. Danicopan, Achillion's lead drug candidate, has received breakthrough therapy designation for treatment, in combination with a C5 monoclonal antibody, for patients with a rare blood disorder paroxysmal nocturnal hemoglobinuria (PNH). Over the past three months, Achillion's stock has rallied 47.8% and Alexion shares have dropped 14.7%, while the iShares Nasdaq Biotechnology ETF has slipped 2.9% and the S&P 500 has eased 0.3%.
The major biotech exchange-traded funds are failing to keep up with the market this year, despite a strong showing in the first few months of the year. Evercore ISI analysts Ravi Mehrotra and Josh Schimmer suggest that gene therapy might be the reason. The analysts wrote in a Sunday note that they had constructed a proprietary index of gene therapy companies, and found the companies had “massively” underperformed in the second half of the year.
Venture capitalists are pouring cash into U.S. biotechs at a rate set to replicate 2018’s record deal count, according to PitchBook and the National Venture Capital Association’s third-quarter Venture Monitor report. In the first three quarters alone, VCs struck 609 biopharma deals — the majority of which were Series A or B — and contributed $11.5 billion in investments. Compared to the stretch between 2005 and 2011, VC investments more than tripled to strike $2.3 billion between 2012 and 2018. What Does The VC Landscape Look Like?
It’s no secret that healthcare stocks have been under pressure due to geopolitical uncertainty, increased government regulation, and ongoing pressure on drug companies to lower prices. Take a look at the Biotechnology ETF (IBB) and see how badly the sector is underperforming.However, the greatest investment advice of all time comes from the Oracle of Omaha, Warren Buffett. He advised investors to be greedy when others are fearful and to be fearful when others are greedy. In short, Buffett believes the best way to make money on Wall Street is to look for quality companies that have fallen on hard times.Indeed, there are several “strong buy” stocks in the sector, which are set for significant gains in the coming months -- at least, according to Wall Street analysts. We turned to TipRanks’ Stock Screener to see which healthcare stocks these analysts believe have plenty of upside potential ahead. That’s according to the upside potential from the average analyst price target. Let’s see how that works out now: Is HCA Healthcare Stock Setting Up for a Large Move Higher?Ranked No. 67 in the 2019 Fortune 500 list as the largest United States corporations by total revenue, HCA Healthcare (HCA) manages approximately 2,000 care sites, including 184 hospitals, urgent care centers, and physician clinics, 119 freestanding surgery centers, and ER’s in the United States and United Kingdom. This September, HCA opened a new $10 million-dollar medical facility in Orlando, Florida; its third freestanding ER launch this year, bringing the company's net worth value to $43.24 billion. In addition, HCA has started construction in partnership with the University of Central Florida on a $175 million teaching hospital, The UCF Lake Nona Medical Center, set to open in fall 2020. 5-star Wolfe analyst Justin Lake believes that a "combination of significantly lower expectations and valuation leaves an increasingly interesting risk/reward." Despite near-term uncertainty about "general lack of visibility on mix/acuity and tough comps," the analyst sees "potential that 2Q results were simply white noise, similar to UHS 1Q19, which coupled w/modest cost cuts and extra biz day in qtr. leaves potential for 3Q rebound." Lake rates HCA a Buy with $141 price target, which implies about 22% upside from current levels. (To watch Lake's track record, click here)Lake is not the only fan of the healthcare provider on Wall Street, as TipRanks analytics exhibit HCA as a Strong Buy. Based on six analysts polled by in the last three months, five rate HCA a Buy, while only one rates the stock a Hold. The 12-month average price target stands at $157.17, marking a 37% upside from where the stock is currently trading. (See HCA's price targets and analyst ratings on TipRanks) Zoetis Stock Still Has Gasoline Left in the TankWith over 65 years of experience in animal health, Zoetis (ZTS) is what many believe to be the “go-to” developer and manufacturer of medicines, vaccines, biodevices, and diagnostic products for pets and livestock. The company sells its products in more than 100 countries worldwide and now boasts over 10,000 employees; virtually dominating the global animal health market. Zoetis stock has been knocking it out of the ballpark so far this year, rising by a whopping 43%, and Wall Street analysts say there’s still some gas left in the tank.5-star Stifel analyst Jonathan Block mentioned that the company's Q2 Animal Health survey showed how well ZTS’s product pipeline is doing, having him predict an upside on the company’s 2019-2022 revenue and ESP estimates. “The Triple”, feline pain, canine pain, and feline atopic dermatitis accounted for the vast majority of pharmaceutical product innovations that Veterinarians want, all of which Zoetis could or should bring into the market over the next 1-2+ years,” Block went on to say. Block rates ZTS a 'buy' with $140 price target, which implies about 14% upside from current levels. (To watch Block's track record, click here)TipRanks reveals the veterinary drug and vaccine maker as one drawing bullish attention on Wall Street. Out of 10 analysts polled in the last 3 months, 8 rate a Buy on AMD stock, 2 maintain a Hold. The 12-month average price target stands at $137.33, marking a nearly 12% upside potential from where the stock is currently trading.(See ZTS's price targets and analyst ratings on TipRanks)Is Alexion Stock Set to Jump Over 60%?Alexion (ALXN) is a global biopharmaceutical company focusing on treatment for rare diseases through the discovery and development of advanced medical therapies. The company is best known for its development of $3 billion-a-year bestseller Soliris, a drug used to treat the rare disorders ‘atypical Hemolytic Uremic Syndrome’ (aHUS) and ‘Paroxysmal Nocturnal Hemoglobinuria’. Due to the high cost of Soliris and its niche nature, the company continues to reign undefeated in the rare diseases sector and sees high-profit margins year-over-year. In addition, Alexion recently announced that it is replacing its CFO Paul Clancy with Aradhana Sarin, M.D., the company’s chief strategy and business officer. Sarin is responsible for $2 billion in recent pipeline acquisitions and has a strong M&A background. This shift into new leadership has analysts a little excited, one would say. 5-star RBC Capital analyst Kennen MacKay reiterated an Outperform rating (i.e. Buy) on ALXN stock, stating that he sees “Dr. Sarin as a strong successor given her prior position as Senior Vice President in Business and Corporate Strategy.” Adding that Sarin “has led ALXN's business development efforts including what view as an impressive string of acquisitions and partnerships.” All in all, Alexion stock has one of the best ratings by the Street. TipRanks reveals that ALXN has a Strong Buy analyst consensus rating with 12 'buy' ratings and only one 'hold' rating in the last three months. Meanwhile the average analyst price target of $163.30 suggests the stock has upside potential of nearly 66% from the current share price for the next 12 months. (See ALXN's price targets and analyst ratings on TipRanks)
Here is a look at ETFs that currently offer attractive short selling opportunities. The ETFs included in this list are rated as sell candidates for two reasons. First, each of these funds is deemed to be in a downtrend based on the fact that its 50-day moving average is below its 200-day moving average, which are popular indicators for gauging long-term and medium-term trends, respectively. Second, each of these ETFs is also trading above its 20-day moving average, thereby offering a near-term 'sell on the pop' opportunity given the longer-term downtrend at hand. Note that this prospects list also features a liquidity screen by excluding ETFs with average trading volumes below the one million shares mark. As always, investors of all experience levels are advised to use stop-loss orders and practice disciplined profit-taking techniques. To get access to all ETFdb.com premium content, sign up for a free 14-day trial to ETFdb.com Pro.
Take a look at the Biotechnology ETF (NASDAQ:IBB) and investors will notice how badly the sector is underperforming. Though it is up by around 9% year-to-date, the S&P 500 (NYSE:SPY) is up by 15.6% while the Nasdaq (NASDAQ:QQQ) is up by 20%. Government scrutiny over drug pricing and the high-cost structure of the healthcare system in the U.S. is hurting biotech stocks, too.Company-specific news is also weighing on specific biotechnology stocks. Those are the ones investors should watch. But as disappointing developments send such stocks lower, which ones should investors buy or sell? Volatility is increasing in markets and is triggered by an inverted yield curve and trade tensions between the U.S. and China. This creates wider price movements for biotech stocks, opening up better entry and exit points for investors. * 10 Undervalued Stocks With Breakout Potential What are the nine biotech stocks to watch amid the uncertainties ahead?InvestorPlace - Stock Market News, Stock Advice & Trading Tips Regeneron Pharmaceuticals (REGN)Source: Shutterstock Regeneron Pharmaceuticals (NASDAQ:REGN) started 2019 on a positive note when shares rose steadily and topped $440 by March. Since then, however, even a strong quarterly earnings report, posted on Aug 6, has failed to move the stock higher.Regeneron reported non-GAAP earnings per share of $6.02. GAAP EPS was $1.68 after revenue grew 19.9% Y/Y to $1.93 billion. Market share for EYLEA grew to 71% of net product sales. And Regeneron has a plan to develop Eylea's position in diabetic retinopathy. It is educating physicians and patients with the drug as a first-line anti-VEGF treatment.Sales of Dupixent, which treats patients suffering from Type 2 inflammatory diseases -- atopic dermatitis, asthma, and now chronic rhinosinusitis with nasal polyposis - grew 151% Y/Y. Net sales in Q2 was $557 million. Total prescriptions grew 30% sequentially, driven by the growth in approved indications. Its approval for treating atopic dermatitis for adolescents will ensure the drug's continued growth.Non-GAAP R&D expenses rose to $589 million, up from $470M Y/Y. Continued investments in its research platform and pipeline will pay off if the company's history is an indication.This report shows that Regeneron stock has substantial upside potential from here. If Dupixent sales continue growing in the 150% range, Regeneron stock trading at 12-times forward earnings is too low. Amarin (AMRN)Source: Shutterstock Amarin (NASDAQ:AMRN) was up over 30% year to-date -- until August 8. Then ARMN stock fell 23% after-hours when the FDA pushed back an advisory committee date for it's drug Vascepa.So markets will have to wait for the review and discussion of Amarin's supplemental marketing application seeking a cardiovascular benefit claim for Vascepa. But even without the label expansion, Vascepa's projected revenue is $400 million annualized. In Q2 2019, net total revenue was $100.8 million. Increased Vascepa prescription volume from prior and new prescribers lifted sales.The company also has plans to double its number of sales reps to 800 by October. This will allow them to expand the number of targeted healthcare professionals from ~50,000 to up to 80,000. Performing more sales calls to prescribers, assisting physicians in the familiarization with Vascepa, and a direct to consumer campaign will support product growth. And despite the FDA setback, Amarin raised its 2019 full-year revenue guidance to $380 million to $420 million. For the current Q3 period, the Vascepa normalized TRx will exceed 700,000. * 10 Mid-Cap Dividend Stocks to Buy Now On the balance sheet, Amarin has $661 million in cash and cash equivalents, lifted from a $440 million equity offering in July 2019. Since it will not need to sell more shares in the near future, investors only need to worry about the FDA decision next. Arena Pharmaceuticals (ARNA)Source: Shutterstock Arena Pharmaceuticals dipped to below $52.50 in the days following its earnings report posted on Aug. 8. The company reported an EPS GAAP loss of $1.24 as revenue fell 74.$ Y/Y to $1.02 million. Profits and revenue growth are not expected from Arena in the near future. It is still in the development stage. And although it has a promising pipeline cautious investors may want to avoid the stock for now.In the second quarter, the company highlighted its key clinical and regulatory goals. It started two trials: the etrasimod Phase 3 ELEVATE UC 52 trial and the olorinab Phase 2 CAPTIVATE trial. Etrasimod is an oral, once-daily selective sphingosine-1-phosphate (S1P) receptor modulator. The drug treats multiple immune and inflammatory diseases, such as ulcerative colitis. The Elevate UC 52 trial has a 12-week induction period followed by 40 weeks of maintenance. Arena started the trial in June. The Elevate UC 12 is also a 12-week trial that will be started at a later date.Arena spent $51.2 million in R&D in the second quarter, while SG&A totaled $18.4 million. The net loss was $1.24 a share, or $61.4 million. With cash and cash equivalents of over $1.2 billion, investors need not worry about the company issuing shares to raise cash in the near-term. CRISPR Therapeutics (CRSP)Source: Shutterstock Gene editing is a very hot area and CRISPR (NASDAQ:CRSP) stock's uptrend reflects that. CRISPR's mandate is to create transformative gene-based medicines for serious diseases. The company advanced CRISPR in the clinic with CTX001 in beta-thalassemia and sickle cell disease. The gene-edited allogeneic cell therapies -- CTX110, CTX120, and CTX131 -- are considered the next-generation immune-oncology platform. The company's solution enables regenerative medicine through the CRISPR/Cas9-edited allogeneic stem cells.CRISPR has a deep pipeline of programs, with most of them still in the research phase. Still, it has three programs in the clinical phase. After it completes enrollment, investors will have plenty of clinical data to interpret in the years ahead. Patients with Sickle Cell Disease (SCD) and beta-Thalassemia, both of which are a hemoglobinopathy, suffer from anemia, pain, and even early death. By editing the gene, the company aims to mimic variants of naturally occurring hereditary persistence of fetal hemoglobin.The first step of the clinical trial, following enrollment of 45 adult patients, is to assess the safety and efficacy of CTX001. Mice studies suggest it may achieve 80% allelic editing, over 90% of cells modified, and over 30% HbF. * Major Headlines Mean Opportunities for Smart Investors CRISPR is in a hot area of gene editing and if it can treat patients successfully, the value of the company will soar. United Therapeutics (UTHR)Source: Shutterstock United Therapeutics (NASDAQ:UTHR) stock enjoyed the $110 - $120 range up until March. Then the company's declining revenue growth in Q4/2018 began scaring off investors. But by the second quarter, performance improved. The company reported non-GAAP EPS of $3.63, $0.89 higher than consensus. GAAP EPS was $4.66. United Therapeutics reported revenue of $373.6 million, falling 16% from last year.Its prostacyclin product franchise (Remodulin, Tyvaso, and Orenitram), is being used by patients to treat pulmonary arterial hypertension. The company is advancing the drug delivery systems and has late-stage clinical programs in cardiopulmonary diseases. The company's management is set on tripling its business over the next few years. This is possible with a dozen products in its pipeline and many FDA-approved product platforms. It has three new Remodulin products in the pipeline, and after these products gain FDA approval, United's sales could triple.In the COPD and interstitial lung disease space, the company awaits for approval for Tyvaso. And new indications for Uptravi, which treats pulmonary hypertension, will also drive sales higher.In the near-term, generic competition for Remodulin is moderating in the U.S. and in the EU. And as new products come online, markets will realize UTHR stock at a forward P/E of 9.5 times is too low. Exelixis (EXEL)Source: Shutterstock Exelixis (NASDAQ:EXEL) posted Q2 results on July 31. Its non-GAAP EPS was $0.29, while GAAP EPS was $0.25, down 11% from last year. Cabometyx is its best-in-class TKI driving its growth. Revenue rose 29.1% Y/Y to $240.3 million. $46.6 million of that revenue came from collaboration. This included a $20 million milestone from Daiichi Sankyo for the commercial launch of Minnebro tablets for the treatment of hypertension.The company ended the quarter with cash and cash equivalents of $1.16 billion.Exelixis forecast COGS (cost of goods sold) to be between 4% and 5% of net product revenues. R&D expenses will be between $330 million and $350 million. SG&A will be between $220 million - $240 million.Exelixis has four ongoing pivotal trials. It initiated three Phase 3 studies since late 2018 and early 2019. The company is now actively enrolling patients worldwide. Management is optimistic with positive data from its ongoing pivotal trials in first-line RCC and first-line HCC refractory DTC. Investors also believe the company's strong prospects, although EXEL stock trades at a P/E of just 10.6 times.Exelixis increased expenses in the second quarter, with R&D spending up 93%. These efforts will pay off as the company wins more indications for Cabometyx. The drug is the number one prescribed for TKI in RCC. * 10 Undervalued Stocks With Breakout Potential In the near term, strong efficacy data and overall survival benefit numbers will drive demand for Cabometyx higher. Nektar Therapeutics (NKTR)Source: Shutterstock On Aug 9, Nektar Therapeutics (NASDAQ:NKTR) revealed a "softening in response rates" in its Phase 1/2 PIVOT-02 study. This evaluated NKTR-214 with Bristol-Myers Squibb's (NYSE:BMY) Opdivo. The problem is that two of its earliest production patches of bempeg were different than the other 20 batches produced. This would explain the outlier variances as more clinical data matured and became available.As a result of this discovery, Nektar developed a comprehensive control strategy to limit variances in raw materials. But it also means it may build new IP around the product using new assays and control strategies.On its conference call, the company said Bristol-Myers is still committed to the bempeg development program:They remain very committed to the bempeg development program, particularly in light of the recent breakthrough designation in melanoma and the tremendous opportunity for both companies. They are highly committed to the ongoing registrational trials in first-line melanoma, first-line urothelial cancer, and first-line renal cell carcinoma, as well as our new expansion cohort of second-line non-small cell lung cancer patients in PIVOT.NKTR shares may not rebound for a while until it reports updated data from its studies. Novo Nordisk (NVO)Source: Shutterstock Novo Nordisk (NYSE:NVO) is firing on all cylinders after reporting revenue growth of 9.6% Y/Y. Its diabetes and obesity reported combined sales growth of 10% and 6% and constant exchange rates. The company's product pipeline grew after it had a handful of product approvals and filings since May. For example, in Japan, it filed its semaglutide for treating Type II diabetes.For 2019, Novo forecast operating profit growth in the range of 4% to 6%.Novo's diabetes drug is a revenue growth driver. As the global diabetes market leadership rose to 28.3%. its insulin volume market share increased. Additionally, market share grew after Novo launched Ozempic in 18 European markets. In the U.S., Opempic's launch led to a stabilization in the TRx market share at around 45%.Sales of Saxenda, which is a weight-loss drug, increased 56% in the first half of 2019. Novo Nordisk's market share is 50%. And now that it has been launched in 43 countries, the company will invest in market development activities to drive sales.Although Novo stock is trading at close to its 52-week high, this is justified by the higher sales forecast. Investment opportunities and R&D activities starting in the second half of the year will ensure that the company maintains its pace of growth.Disclosure: As of this writing, the author did not hold a position in any of the aforementioned securities. More From InvestorPlace * 2 Toxic Pot Stocks You Should Avoid * 10 Cheap Dividend Stocks to Load Up On * The 10 Biggest Losers from Q2 Earnings * 5 Dependable Dividend Stocks to Buy The post 8 Biotech Stocks to Watch After the Q2 Earnings Season appeared first on InvestorPlace.
Biotech stocks went about in a steady manner this week amid a slew of big pharma and biotech earnings announcements, a handful of FDA approvals and a few clinical trial readouts. Lexicon Pharmaceuticals, ...
U.S. equities slipped lower on Thursday as investors continued to digest a heavy flow of earnings reports. There have been some disappointment as well surrounding a lack of specifics from European Central Bank President Mario Draghi, who has been jawboning fresh stimulus but hasn't yet actually taken action.Some weakness in key industrial and technology stocks has weighed on sentiment. Now, biotech stocks are coming under pressure as well. The Nasdaq Biotechnology ETF (NASDAQ:IBB) is falling away from its 200-day moving average, falling down what looks like the right shoulder of a head-and-shoulders reversal pattern going back to 2017. * 7 Oversold Stocks To Buy Right Now Here are four biotech stocks helping lead the decline:InvestorPlace - Stock Market News, Stock Advice & Trading Tips Biotech Stocks: Vertex Pharmaceuticals (VRTX)Shares of Vertex Pharmaceuticals (NASDAQ:VRTX) stock, which focuses on cystic fibrosis treatments, are falling away from their 50-day and 200-day moving averages to return to the April-June trading range. This marks the latest test of uptrend channel support going back to late 2017. Coverage of this biotech stock was recently resumed at Citigroup, which assigned a buy rating and a $205 price target.The company will next report results on July 31 after the close. Analysts are looking for earnings of $1.08 per share on revenues of $886.3 million. When the company last reported on April 30, earnings of $1.14 beat estimates by 13 cents per share on a 34.3% rise in revenues. Regeneron Pharmaceuticals (REGN)Shares of Regeneron Pharmaceuticals (NASDAQ:REGN), maker of treatments including EYLEA for wet age-related macular degeneration, have fallen back below their 50-day moving average and look set for a test of vital support near its early 2018 lows around $290. This marks the bottom of a trading range going all the way back to 2014, so a breakdown would open the door to a major reversal of the gains posted between 2010 and 2015 that resulted in a 23x rally. * 7 Stocks to Sell This Summer Earnings Season The company will next report results on Aug. 6 before the bell. Analysts are looking for earnings of $5.44 per share on revenues of $1.8 billion. When the company last reported on May 7, earnings of $4.45 missed estimates by $1.07 per share on a 13.3% rise in revenues. Alexion Pharmaceuticals (ALXN)Shares of Alexion Pharmaceuticals (NASDAQ:ALXN), which makes various medications including a treatment for genetic blood disorders, are falling away from their 200-day moving average to threaten a decline below its late May low near $115. This marks nearly a 20% decline from its April high.The company reported better-than-expected results on Wednesday, with earnings of $2.64 per share beating estimates by 30 cents. Forward guidance was raised as well. Yet it appears the whisper number was higher, as investors sold on the report. The company will next report results on Oct. 23 before the market. Incyte (INCY)Shares of Incyte (NASDAQ:INCY) stock, which is a maker of various cancer treatments among other drugs, is falling away from double-top resistance near the $90-a-share threshold and is once again threatening a decline below its 200-day moving average. Shares enjoyed a lift last month on the premium purchase of Array BioPharma (NASDAQ:ARRY), maker of treatment for certain BRAF-mutant cancers, by Pfizer (NYSE:PFE). * 10 Stocks to Buy From This Superstar Fund The company will next report results on July 30 before the bell. Analysts are looking for earnings of 49 cents per share on revenues of $496.6 million. When the company last reported on April 30, earnings of 62 cents per share beat estimates by 21 cents on a 30.2% rise in revenues.As of this writing, William Roth did not hold a position in any of the aforementioned securities. More From InvestorPlace * 2 Toxic Pot Stocks You Should Avoid * 7 Oversold Stocks To Buy Right Now * 7 Stocks to Buy Upgraded by Wall Street * 7 Marijuana Stocks With Critical Levels to Watch The post 4 Biotech Stocks Sliding Lower appeared first on InvestorPlace.
Biotechnology stocks and sector-related exchange traded funds stood out on Tuesday after a U.S. District Court overruled President Donald Trump’s wishes to require drugmakers list prices on television ...
Late Monday, a U.S. District Court overturned President Trump's requirement that pharmaceutical companies and biotech stocks list the prices of their medicines in TV ads.