| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | CHIESI FARMACEUTICI SPA Beneficial Owner (10% or more) | Acquisition (Non Open Market) 14-Oct-09 | 13,772,425 14-Oct-09 | COLLARD CRAIG A Officer | Sale 28-Jul-09 | 3,396,138
28-Jul-09 | CORNERSTONE BIOPHARMA HOLDINGS, LTD. Beneficial Owner (10% or more) | Sale 28-Jul-09 | 1,952,225 28-Jul-09 | DICKSON BRIAN Officer | Sale 2-Sep-09 | 0 2-Sep-09 | FRANKLIN JOSHUA B Officer | Option Exercise 11-Sep-09 | 50,000 11-Sep-09 | LUTZ STEVEN MICHAEL Officer | Sale 28-Jul-09 | 327,348
28-Jul-09 | MCEWAN ALASTAIR STUART Director | Sale 19-Jun-09 | 0 19-Jun-09 | POWELL ANDREW KENNETH WILLIAM Officer | Acquisition (Non Open Market) 30-Oct-09 | 112,000 30-Oct-09 | PRICE DAVID Officer | Sale 3-Sep-09 | 175,133 3-Sep-09 | ROBERTS ALAN Officer | Ownership Statement 30-Oct-09 | 64,100 30-Oct-09 | TOWNSEND SCOTT B Officer | Sale 18-May-09 | 113,043 18-May-09 |
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