| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | GRUBER & MCBAINE CAPITAL MANAGEMENT LLC | 7,549,727 | 8.35 | $10,343,125 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 2,874,813 | 3.18 | $3,938,493 | 30-Sep-09 | | FMR LLC | 2,535,206 | 2.80 | $3,473,232 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 2,431,501 | 2.69 | $3,331,156 | 30-Sep-09 | | HAMBRECHT & QUIST CAPITAL MANAGEMENT, INC. | 2,145,147 | 2.37 | $2,938,851 | 30-Sep-09 | | WELLINGTON MANAGEMENT COMPANY, LLP | 1,577,000 | 1.74 | $2,160,490 | 30-Sep-09 | | DIMENSIONAL FUND ADVISORS LP | 1,471,010 | 1.63 | $2,015,283 | 30-Sep-09 | | KENNEDY CAPITAL MANAGEMENT, INC. | 1,080,777 | 1.20 | $1,480,664 | 30-Sep-09 | | STATE STREET CORPORATION | 1,006,125 | 1.11 | $1,378,391 | 30-Sep-09 | | Invesco Ltd. | 929,121 | 1.03 | $1,272,895 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | FIDELITY SELECT PORTFOLIOS - BIOTECHNOLOGY | 2,396,527 | 2.65 | $3,283,241 | 30-Sep-09 | | H&Q HEALTHCARE INVESTORS | 1,321,151 | 1.46 | $1,136,189 | 31-Mar-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 842,681 | .93 | $1,221,887 | 31-Oct-09 | | ISHARES RUSSELL 2000 INDEX FD | 827,389 | .92 | $1,133,522 | 30-Sep-09 | | H&Q LIFE SCIENCES INVESTORS | 823,996 | .91 | $708,636 | 31-Mar-09 | | DFA U.S. MICRO CAP SERIES | 788,259 | .87 | $662,137 | 30-Apr-09 | | VANGUARD SMALL-CAP INDEX FUND | 698,943 | .77 | $845,721 | 30-Jun-09 | | VANGUARD SMALL-CAP GROWTH INDEX FUND | 449,566 | .50 | $543,974 | 30-Jun-09 | | ISHARES RUSSELL 2000 GROWTH INDEX FD | 441,226 | .49 | $604,479 | 30-Sep-09 | | VANGUARD EXTENDED MARKET INDEX FUND | 383,587 | .42 | $464,140 | 30-Jun-09 |
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Value shown is computed using the security's price on the report date given.
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