Blueprint Medicines Highlights Detailed Data From Lead Product In Blood Cancer Patients

• Blueprint Medicines Corporation (NASDAQ: BPMC) announced detailed results from the PIONEER Phase 2 trial of Ayvakit (avapritinib) in patients with indolent systemic mastocytosis (SM).

• As previously reported, Ayvakit achieved statistically significant and clinically meaningful improvements on the primary and all key secondary endpoints.

• New results further highlight the benefits of Ayvakit on pathological mast cell burden, disease symptoms – including total symptom score (TSS), most severe symptom, and all individual symptoms – and quality of life.

• Across clinical measures, improvements continued to deepen over time in patients treated with Ayvakit through 48 weeks.

• Related: Data From Blueprint Medicines' Blood Disorder Trial Fails To Lift Shares.

• Ayvakit achieved a statistically significant and clinically meaningful improvement in total symptom scores that deepened over time, showing improvements across all individual symptoms.

• Ayvakit had a favorable safety profile compared to placebo, supporting the potential for chronic treatment. 96% of patients in the Ayvakit arm opted to continue treatment in the open-label extension study.

• Blueprint Medicines regained global commercialization and development rights to Gavreto (pralsetinib), excluding Greater China, following a decision by Roche Holdings AG (OTC: RHHBY) to discontinue the collaboration agreement for strategic reasons.

• Price Action: BPMC shares traded 1.92% higher at $38.70 on the last check Monday.

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