IDEAYA Biosciences Touts Encouraging Data From Combo Therapy For Rare Eye Cancer Impacting Around 14,000 In US and Europe

Vandana Singh
2 min read
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In this article:

  • IDEAYA Biosciences Inc (NASDAQ: IDYA) announced further interim results from its Phase 2 clinical trial evaluating darovasertib and crizotinib combination in metastatic uveal melanoma (MUM) type of eye cancer.

  • Confirmed overall response rate (ORR) of 45%, disease control rate (DCR) of 90%, and median progression-free survival (PFS) of ~7 months in 20 evaluable First-Line MUM patients.

  • In the sixty-three (63) evaluable any-line MUM patients at the expansion dose, a confirmed overall response rate (ORR) of 30%, disease control rate (DCR) of 87%, and median PFS of ~7 months was observed.

  • Twenty (20) evaluable hepatic-only MUM patients, including first-line and pre-treated patients with only hepatic metastases, confirmed ORR of 35%, DCR of 100%, and median PFS of ~11 months.

  • IDEAYA plans to initiate a potential registration-enabling Phase 2/3 clinical trial in Q2 2023 in first-line HLA-A2 negative MUM patients.

  • The company observed further evidence of clinical activity for darovasertib as neoadjuvant therapy in primary uveal melanoma (UM), including responses in primary ocular tumor lesions.

  • Ocular tumor shrinkage in 9 of 9 (100%) UM / MUM patients, including a neoadjuvant UM patient with a partial response at 1 month and a second neoadjuvant UM patient who was spared enucleation with ~80% tumor shrinkage at four months.

  • IDEAYA is initiating a company-sponsored clinical trial to evaluate darovasertib as monotherapy in (neo)adjuvant uveal melanoma and is evaluating potential near-term clinical neoadjuvant endpoints such as organ preservation (avoiding enucleation) for large ocular tumors and reduction in radiation dose and/or vision preservation for small or medium ocular tumors.

  • Price Action: IDYA shares are up 27.30% at $19.01 on the last check Monday.

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This article IDEAYA Biosciences Touts Encouraging Data From Combo Therapy For Rare Eye Cancer Impacting Around 14,000 In US and Europe originally appeared on Benzinga.com

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