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Vascular Biogenics' Ovarian Cancer Gene Therapy Study To Continue, Recommends An Independent Committee

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Vandana Singh
·1 min read
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  • Vascular Biogenics Ltd (NASDAQ: VBLTannounces results from the independent Data Safety Monitoring Committee (DSMC) pre-planned review of the ongoing OVAL Phase 3 study of VB-111 in recurrent ovarian cancer.

  • According to the results, the committee found no safety issues with the trial and recommended its continuation.

  • The following DSMC review is scheduled for the third quarter of 2021, followed by completion of enrollment at the end of 2021 or in early 2022

  • In March last year, interim analysis in the OVAL study demonstrated an overall response rate of 53%. The response rate in the treatment arm (VB-111 in addition to weekly paclitaxel) was at least 10% higher than in the control arm. According to the Company update in November, a high response rate of greater than 50% in the total evaluable patient population was maintained with approximately 200 patients enrolled.

  • VB-111 (ofranergene obadenovec) is an investigational targeted anti-cancer gene-therapy that uses a dual mechanism to target solid tumors. Its mechanism combines the blockade of tumor vasculature with an anti-tumor immune response. VB-111 is administered as an IV infusion once every 6-8 weeks.

  • Price Action: VBLT is up 5.29% at $2.42 in market trading hours on the last check Monday.

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