| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | ALTA BIOPHARMA PARTNERS II LP
Beneficial Owner (10% or more) | Purchase
16-Oct-09 | 5,664,267
16-Oct-09 | ANDERSON DAVID L
Beneficial Owner (10% or more) | Purchase
16-Oct-09 | 289,747
16-Oct-09 | ANDERSSON ALLEN
Director | Sale
7-May-09 | 209,694
7-May-09 | BAKER G LEONARD JR
Director | Purchase
16-Oct-09 | 792,268
16-Oct-09 | BIRD JEFFREY W
Beneficial Owner (10% or more) | Purchase
16-Oct-09 | 126,252
16-Oct-09 | COOK JOSEPH C JR
Director | Purchase
16-Oct-09 | 703,984
16-Oct-09 | COXE TENCH
Beneficial Owner (10% or more) | Purchase
16-Oct-09 | 360,048
16-Oct-09 | ENRIGHT PATRICK G
Director | Purchase
16-Oct-09 | 10,970,285
16-Oct-09 | GAITHER JAMES C
Beneficial Owner (10% or more) | Purchase
6-Feb-09 | 4,338,742
6-Feb-09 | LOEWY CAROLINE M
Officer | Ownership Statement
28-Nov-08 | 0
28-Nov-08 | LONGITUDE VENTURE PARTNERS L.P.
Director | Purchase
16-Oct-09 | 10,970,285
16-Oct-09 | MAHONEY DAVID L
Director | Purchase
16-Oct-09 | 1,069,110
16-Oct-09 | MARDUEL ALIX
Director | Purchase
25-Mar-08 | 5,043,299
25-Mar-08 | PAPERBOY VENTURES, LLC
Director | Sale
7-May-09 | 209,694
7-May-09 | PENHOET EDWARD
Director | Purchase
16-Oct-09 | 5,484,063
16-Oct-09 | SANDS GREGORY P
Beneficial Owner (10% or more) | Purchase
16-Oct-09 | 109,913
16-Oct-09 | SHEEHAN ANDREW T
Beneficial Owner (10% or more) | Purchase
16-Oct-09 | 18,325
16-Oct-09 | SPEISER MICHAEL L
Beneficial Owner (10% or more) | Purchase
6-Feb-09 | 4,338,742
6-Feb-09 | SUTTER HILL VENTURES
Beneficial Owner (10% or more) | Purchase
16-Oct-09 | 5,217,464
16-Oct-09 | SWEET DAVID E
Beneficial Owner (10% or more) | Purchase
16-Oct-09 | 18,480
16-Oct-09 | WHITE JAMES N
Beneficial Owner (10% or more) | Purchase
16-Oct-09 | 121,117
16-Oct-09 | WILSON JAMES N
Director | Purchase
10-Feb-09 | 951,774
10-Feb-09 | YOUNGER WILLIAM H JR
Beneficial Owner (10% or more) | Purchase
16-Oct-09 | 575,066
16-Oct-09 |
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