| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 24-Aug-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 4,552,550 | Direct | Sale at $2.57 per share. | $11,700,053 | | 1-Jul-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 142,700 | Direct | Sale at $2.97 per share. | $423,818 | | 29-Jun-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 58,616 | Direct | Sale at $2.94 per share. | $172,331 | | 26-Jun-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 479,256 | Direct | Sale at $2.93 per share. | $1,404,220 | | 25-Jun-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 291,393 | Direct | Sale at $2.87 - $2.9 per share. | $841,0002 | | 7-Apr-09 | KNOTT DAVID M Director | 826,600 | Indirect | Purchase at $2.60 per share. | $2,149,160 | | 7-Apr-09 | KNOTT DAVID M Director | 438,800 | Indirect | Sale at $4.60 per share. | $2,018,479 | | 25-Feb-09 | DZIEWANOWSKA ZOFIA E Officer | 6,000 | Direct | Sale at $2.62 per share. | $15,720 | | 17-Feb-09 | KNOTT DAVID M Director | 826,600 | Indirect | Purchase at $2.60 per share. | $2,149,160 | | 17-Feb-09 | KNOTT DAVID M Director | 826,600 | Indirect | Sale at $4.60 per share. | $3,802,359 | | 15-Feb-09 | KAZMI SYED Officer | 18,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 15-Feb-09 | BERKMAN CHARLES S Officer | 18,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 15-Feb-09 | SHARP JOHN P Officer | 18,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 15-Feb-09 | MEGLASSON MARTIN Officer | 20,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 15-Feb-09 | HIGGINS JOHN L Officer | 75,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 26-Jan-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 4,008 | Indirect | Purchase at $2 per share. | $8,016 | | 23-Jan-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 39,728 | Indirect | Purchase at $2 per share. | $79,456 | | 23-Dec-08 | BURAKOFF STEVEN J Director | 10,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 23-Dec-08 | BURAKOFF STEVEN J Director | 10,000 | Direct | Statement of Ownership | N/A | | 23-Dec-08 | PEACOCK BRUCE Director | 10,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 23-Dec-08 | PEACOCK BRUCE Director | 10,000 | Direct | Statement of Ownership | N/A | | 5-Dec-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 28,283 | Indirect | Purchase at $1.98 per share. | $56,000 | | 4-Dec-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 96,300 | Indirect | Purchase at $2.04 per share. | $196,452 | | 3-Dec-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 27,739 | Indirect | Purchase at $1.95 per share. | $54,091 | | 2-Dec-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 193,000 | Indirect | Purchase at $1.90 per share. | $366,700 | | 1-Dec-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 131,700 | Indirect | Purchase at $1.86 per share. | $244,961 | | 28-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 240,600 | Indirect | Purchase at $1.99 per share. | $478,794 | | 26-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 1,350,000 | Indirect | Purchase at $1.93 - $1.97 per share. | $2,633,0002 | | 25-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 353,000 | Indirect | Purchase at $1.77 per share. | $624,810 | | 24-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 143,000 | Indirect | Purchase at $2.01 per share. | $287,429 | | 21-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 186,744 | Indirect | Purchase at $1.78 per share. | $332,404 | | 20-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 9,200 | Indirect | Purchase at $1.26 per share. | $11,592 | | 19-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 33,000 | Indirect | Purchase at $1.39 per share. | $45,870 | | 18-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 81,400 | Indirect | Purchase at $1.38 per share. | $112,331 | | 17-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 92,000 | Indirect | Purchase at $1.33 per share. | $122,360 | | 14-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 210,000 | Indirect | Purchase at $1.30 - $1.35 per share. | $278,0002 | | 13-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 94,000 | Indirect | Purchase at $1.34 per share. | $125,960 | | 12-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 14,511 | Indirect | Purchase at $1.35 per share. | $19,589 | | 11-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 167,850 | Indirect | Purchase at $1.39 per share. | $233,311 | | 10-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 198,000 | Indirect | Purchase at $1.36 per share. | $269,280 | | 7-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 113,000 | Indirect | Purchase at $1.41 per share. | $159,330 | | 6-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 9,773,948 | Indirect | Statement of Ownership | N/A | | 6-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 5,834,300 | Direct | Statement of Ownership | N/A | | 4-Aug-08 | LIGAND PHARMACEUTICALS INC Director | 10,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 4-Aug-08 | SABBA STEPHEN L Director | 10,000 | Direct | Statement of Ownership | N/A | | 29-May-08 | DAVIS TODD C Director | 5,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 29-May-08 | ARYEH JASON Director | 5,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 29-May-08 | GREETHAM ELIZABETH M Director | 5,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 29-May-08 | KOZARICH JOHN W Director | 5,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 29-May-08 | PERRY JEFFREY R Director | 5,000 | Direct | Acquisition (Non Open Market) | N/A | | 29-May-08 | KNOTT DAVID M Director | 5,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 9-May-08 | MEGLASSON MARTIN Officer | 3,000 | Direct | Purchase at $3.36 per share. | $10,080 | | 9-May-08 | KNOTT DAVID M Director | 512,300 | Indirect | Sale at $3.40 per share. | $1,741,820 | | 9-May-08 | KNOTT DAVID M Director | 512,300 | Indirect | Purchase at $3.40 per share. | $1,741,820 | | 5-Mar-08 | KOZARICH JOHN W Director | 3,000 | Direct | Purchase at $3.66 per share. | $10,980 | | 23-Feb-08 | SHARP JOHN P Officer | 18,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 23-Feb-08 | HIGGINS JOHN L Officer | 75,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 23-Feb-08 | MEGLASSON MARTIN Officer | 10,500 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 23-Feb-08 | KAZMI SYED Officer | 7,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 23-Feb-08 | BERKMAN CHARLES S Officer | 7,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 23-Feb-08 | SHARP JOHN P Officer | 7,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 23-Feb-08 | HIGGINS JOHN L Officer | 28,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 23-Feb-08 | KAZMI SYED Officer | 18,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 23-Feb-08 | DZIEWANOWSKA ZOFIA E Officer | 18,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 23-Feb-08 | BERKMAN CHARLES S Officer | 18,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 23-Feb-08 | MEGLASSON MARTIN Officer | 20,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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