| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | DEUTSCHE BANK AKTIENGESELLSCHAFT | 971,034 | 4.01 | $8,506,257 | 30-Sep-09 | | O.S.S. CAPITAL MANAGEMENT, LP | 6,246,047 | 25.78 | $54,715,371 | 30-Sep-09 | | APG All Pensions Group | 641,158 | 2.65 | $5,616,544 | 30-Sep-09 | | SELZ CAPITAL, LLC | 576,000 | 2.38 | $5,045,760 | 30-Sep-09 | | BVF INC. | 3,595,395 | 14.84 | $31,495,660 | 30-Sep-09 | | GILDER, GAGNON, HOWE & CO. | 450,270 | 1.86 | $3,944,365 | 30-Sep-09 | | Invesco Ltd. | 330,798 | 1.37 | $2,897,790 | 30-Sep-09 | | WS MANAGEMENT, LLP | 284,700 | 1.18 | $2,493,972 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 239,071 | .99 | $2,094,261 | 30-Sep-09 | | ARNHOLD & S. BLEICHRODER ADVISERS INC. | 174,131 | .72 | $1,525,387 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | DWS Global Opportunities Fd | 568,691 | 2.35 | $4,521,093 | 31-Jul-09 | | Powershares Exgh Traded Fd Tr-Powershares Lux Nanotech Port | 378,901 | 1.56 | $3,012,262 | 31-Jul-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 220,533 | .91 | $1,973,770 | 31-Oct-09 | | DWS Var Ser I-DWS Global Opportunities VIP | 190,800 | .79 | $1,335,600 | 30-Jun-09 | | MAINSTAY SMALL COMPANY VALUE FUND | 71,300 | .29 | $499,100 | 30-Jun-09 | | DWS Balanced Fd | 54,400 | .22 | $432,480 | 31-Jul-09 | | PERRITT EMERGING OPPORTUNITIES FUND | 50,500 | .21 | $442,380 | 30-Sep-09 | | DWS Advisor Fds-DWS Small Cap Growth Fd | 36,319 | .15 | $254,233 | 30-Jun-09 | | DWS Var Ser II-DWS Small Cap Growth VIP | 34,500 | .14 | $241,500 | 30-Jun-09 | | DWS Advisor Fds III-DWS Life Cycle Long Range Fd | 22,061 | .09 | $154,427 | 30-Jun-09 |
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Value shown is computed using the security's price on the report date given.
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0.49% Nasdaq 
Major Holders
