| 1.16% | % of Shares Held by All Insider |
| 107.69% | % of Shares Held by Institutions |
| 108.95% | % of Float Held by Institutions |
| 176 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| FMR, LLC | 11,630,784 | Mar 30, 2019 | 14.98% | 338,106,890 |
| Janus Henderson Group PLC | 11,302,434 | Mar 30, 2019 | 14.55% | 328,561,756 |
| Price (T.Rowe) Associates Inc | 7,885,495 | Mar 30, 2019 | 10.15% | 229,231,339 |
| Palo Alto Investors Lp | 7,653,617 | Mar 30, 2019 | 9.85% | 222,490,646 |
| Blackrock Inc. | 7,244,652 | Mar 30, 2019 | 9.33% | 210,602,033 |
| Vanguard Group, Inc. (The) | 7,083,890 | Mar 30, 2019 | 9.12% | 205,928,682 |
| State Street Corporation | 2,841,366 | Mar 30, 2019 | 3.66% | 82,598,509 |
| Baker Brothers Advisors, LLC | 2,077,601 | Mar 30, 2019 | 2.68% | 60,395,861 |
| Foresite Capital Management IV, LLC | 1,533,883 | Mar 30, 2019 | 1.97% | 44,589,978 |
| Vivo Capital, LLC | 1,170,290 | Mar 30, 2019 | 1.51% | 34,020,330 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Fidelity Select Portfolios - Health Care | 2,600,000 | Apr 29, 2019 | 3.35% | 79,144,000 |
| Janus Henderson Global Life Sciences Fund | 2,340,586 | Mar 30, 2019 | 3.01% | 68,040,835 |
| Vanguard Total Stock Market Index Fund | 2,016,978 | Dec 30, 2018 | 2.60% | 26,462,751 |
| Vanguard Small-Cap Index Fund | 1,987,626 | Dec 30, 2018 | 2.56% | 26,077,653 |
| Janus Henderson Research Fund | 1,876,715 | Mar 30, 2019 | 2.42% | 54,556,105 |
| Janus Henderson Contrarian Fund | 1,858,388 | Mar 30, 2019 | 2.39% | 54,023,339 |
| Price (T.Rowe) Health Sciences Fund | 1,702,356 | Mar 30, 2019 | 2.19% | 49,487,488 |
| iShares Russell 2000 ETF | 1,581,276 | Apr 29, 2019 | 2.04% | 48,134,041 |
| Price (T.Rowe) Small Cap Stock Fund | 1,561,139 | Mar 30, 2019 | 2.01% | 45,382,310 |
| Variable Insurance Products Fund-Growth Portfolio | 1,312,783 | Apr 29, 2019 | 1.69% | 39,961,114 |