| 1.16% | % of Shares Held by All Insider |
| 107.69% | % of Shares Held by Institutions |
| 108.95% | % of Float Held by Institutions |
| 176 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Amundi Pioneer Asset Management | 31,029,700 | Jun 29, 2019 | 34.78% | 794,360,320 |
| Janus Henderson Group PLC | 11,664,190 | Jun 29, 2019 | 13.08% | 298,603,264 |
| FMR, LLC | 10,588,716 | Jun 29, 2019 | 11.87% | 271,071,129 |
| Vanguard Group, Inc. (The) | 7,979,937 | Jun 29, 2019 | 8.95% | 204,286,387 |
| Palo Alto Investors Lp | 7,890,917 | Jun 29, 2019 | 8.85% | 202,007,475 |
| Blackrock Inc. | 7,242,412 | Jun 29, 2019 | 8.12% | 185,405,747 |
| Price (T.Rowe) Associates Inc | 7,057,967 | Jun 29, 2019 | 7.91% | 180,683,955 |
| State Street Corporation | 3,180,476 | Jun 29, 2019 | 3.57% | 81,420,185 |
| Baker Brothers Advisors, LLC | 2,462,216 | Jun 29, 2019 | 2.76% | 63,032,729 |
| Citadel Advisors LLC | 2,322,114 | Jun 29, 2019 | 2.60% | 59,446,118 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Janus Henderson Global Life Sciences Fund | 2,370,405 | Jun 29, 2019 | 2.66% | 60,682,368 |
| Janus Henderson Contrarian Fund | 2,143,619 | Jun 29, 2019 | 2.40% | 54,876,646 |
| Vanguard Total Stock Market Index Fund | 2,016,978 | Dec 30, 2018 | 2.26% | 26,462,751 |
| Vanguard Small-Cap Index Fund | 1,987,626 | Dec 30, 2018 | 2.23% | 26,077,653 |
| Janus Henderson Research Fund | 1,876,715 | Jun 29, 2019 | 2.10% | 48,043,904 |
| iShares Russell 2000 ETF | 1,616,732 | Jun 29, 2019 | 1.81% | 41,388,339 |
| SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 1,604,640 | Jun 29, 2019 | 1.80% | 41,078,784 |
| Fidelity Select Portfolios - Health Care | 1,600,000 | Jun 29, 2019 | 1.79% | 40,960,000 |
| Price (T.Rowe) Small Cap Stock Fund | 1,476,739 | Jun 29, 2019 | 1.66% | 37,804,518 |
| Variable Insurance Products Fund-Growth Portfolio | 1,312,783 | Jun 29, 2019 | 1.47% | 33,607,244 |