| MATHIS SCOTT L Chief Executive Officer | Stock Award(Grant) at price 0.28 per share. | Direct | 35,875 | Sep 16, 2022 |
| MOEL STEVEN A M.D., J.D. Director | Stock Award(Grant) at price 0.62 per share. | Direct | 12,541 | Jun 24, 2022 |
| MATHIS SCOTT L Chief Executive Officer | Stock Award(Grant) at price 0.62 - 2.02 per share. | Direct | 1,136,232 | Jun 24, 2022 |
| LAWRENCE PETER JESSEL LEVAY Director | Stock Award(Grant) at price 0.62 per share. | Direct | 12,541 | Jun 24, 2022 |
| ECHEVARRIA MARIA I Chief Financial Officer | Stock Award(Grant) at price 0.62 per share. | Direct | 50,166 | Jun 24, 2022 |
| CANNON REUBEN Director | Stock Award(Grant) at price 0.62 per share. | Direct | 6,271 | Jun 24, 2022 |
| DUMONT MARC Director | Stock Award(Grant) at price 0.81 per share. | Direct | 87,501 | Jun 7, 2022 |
| MOEL STEVEN A M.D., J.D. Director | Stock Award(Grant) at price 0.81 per share. | Direct | 87,501 | Jun 7, 2022 |
| ALLEN A WILLIAM III Director | Stock Award(Grant) at price 0.81 per share. | Direct | 87,501 | Jun 7, 2022 |
| LAWRENCE PETER JESSEL LEVAY Director | Stock Award(Grant) at price 0.81 per share. | Direct | 87,501 | Jun 7, 2022 |
| CANNON REUBEN Director | Stock Award(Grant) at price 0.81 per share. | Direct | 87,501 | Jun 7, 2022 |
| RODRIGUEZ EDIE Director | Stock Award(Grant) at price 0.81 per share. | Direct | 87,501 | Jun 7, 2022 |
| DUMONT MARC Director | Stock Award(Grant) at price 2.02 per share. | Direct | 204,444 | Mar 28, 2022 |
| CANNON REUBEN Director | Stock Award(Grant) at price 2.02 per share. | Direct | 10,268 | Mar 28, 2022 |
| MATHIS SCOTT L Chief Executive Officer | Stock Award(Grant) at price 1.87 - 2.23 per share. | Indirect | 2,410,872 | Mar 25, 2022 |
| ECHEVARRIA MARIA I Chief Financial Officer | Stock Award(Grant) at price 2.23 per share. | Indirect | 16,950 | Mar 25, 2022 |
| MATHIS SCOTT L Chief Executive Officer | Stock Award(Grant) at price 0.00 per share. | Indirect | 0 | Jul 6, 2021 |
| ECHEVARRIA MARIA I Chief Financial Officer | Stock Award(Grant) at price 0.00 per share. | Indirect | 0 | Jul 6, 2021 |
| CANNON REUBEN Director | Purchase at price 6.00 per share. | Direct | 19,998 | Feb 19, 2021 |
| RODRIGUEZ EDIE Director | Purchase at price 6.00 per share. | Direct | 49,998 | Feb 19, 2021 |
| MATHIS SCOTT L Chief Executive Officer | Stock Award(Grant) at price 0.56 per share. | Indirect | 3,778 | Oct 23, 2020 |
| MATHIS SCOTT L Chief Executive Officer | Stock Award(Grant) at price 0.50 per share. | Indirect | 14,720 | Oct 2, 2020 |
| ECHEVARRIA MARIA I Chief Financial Officer | Stock Award(Grant) at price 0.50 per share. | Indirect | 2,902 | Oct 2, 2020 |
| CANNON REUBEN Director | Stock Award(Grant) at price 0.53 per share. | Indirect | 15,588 | Sep 30, 2020 |
| MATHIS SCOTT L Chief Executive Officer | Stock Award(Grant) at price 0.35 per share. | Direct | 7,000 | Mar 15, 2019 |
| MATHIS SCOTT L Chief Executive Officer | Stock Award(Grant) at price 0.35 per share. | Indirect | 10,887 | Mar 13, 2019 |
| ECHEVARRIA MARIA I Chief Financial Officer | Stock Award(Grant) at price 0.35 per share. | Indirect | 1,500 | Mar 13, 2019 |
| MATHIS SCOTT L Chief Executive Officer | Stock Award(Grant) at price 0.70 per share. | Indirect | 1,283 | Jun 18, 2018 |
| MATHIS SCOTT L Chief Executive Officer | Stock Award(Grant) at price 0.70 per share. | Indirect | 31,015 | Apr 4, 2018 |
| ECHEVARRIA MARIA I Chief Financial Officer | Stock Award(Grant) at price 0.70 per share. | Indirect | 1,836 | Apr 4, 2018 |
| MATHIS SCOTT L Chief Executive Officer | Purchase at price 2.50 per share. | Indirect | 54,000 | Apr 19, 2017 |
| ECHEVARRIA MARIA I Chief Financial Officer | Stock Award(Grant) at price 2.00 per share. | Indirect | 1,150 | Apr 19, 2017 |
| FASANO KEITH T. Officer | Purchase at price 0.25 per share. | Indirect | 1,250 | Sep 23, 2016 |
| MATHIS SCOTT L Chief Executive Officer | Purchase at price 2.50 per share. | Indirect | 7,000 | Nov 6, 2015 |
| MATHIS SCOTT L Officer, Director and Beneficial Owner | Purchase at price 2.00 per share. | Indirect | 9,264 | Aug 27, 2015 |
| MATHIS SCOTT L Chief Executive Officer | Purchase at price 2.00 per share. | Indirect | 35,000 | Mar 6, 2015 |