| 0.00% | % of Shares Held by All Insider |
| 60.84% | % of Shares Held by Institutions |
| 60.84% | % of Float Held by Institutions |
| 234 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Harding Loevner LLC | 17,333,270 | Jun 29, 2019 | 6.63% | 365,731,997 |
| Deutsche Bank Aktiengesellschaft | 12,757,103 | Jun 29, 2019 | 4.88% | 269,174,873 |
| AKO Capital LLP | 12,562,923 | Jun 29, 2019 | 4.81% | 265,077,675 |
| FIL LTD | 9,723,223 | Jun 29, 2019 | 3.72% | 205,160,005 |
| Pictet Asset Management Ltd | 6,855,338 | Jun 29, 2019 | 2.62% | 144,647,631 |
| Ameriprise Financial, Inc. | 5,888,142 | Jun 29, 2019 | 2.25% | 124,239,796 |
| First Trust Advisors LP | 5,073,910 | Jun 29, 2019 | 1.94% | 107,059,501 |
| Capital Research Global Investors | 4,336,188 | Jun 29, 2019 | 1.66% | 91,493,566 |
| Black Creek Investment Management Inc. | 3,700,654 | Jun 29, 2019 | 1.42% | 78,083,799 |
| Norges Bank Investment Management | 3,145,298 | Dec 30, 2018 | 1.20% | 57,747,671 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| First Trust NYSE Arca Biotechnology Index Fund | 5,120,941 | Mar 30, 2019 | 1.96% | 102,982,123 |
| Europacific Growth Fund | 3,541,478 | Jun 29, 2019 | 1.35% | 74,725,185 |
| Harding, Loevner Funds, Inc-International Equity Portfolio | 3,211,912 | Jan 30, 2019 | 1.23% | 59,805,801 |
| iShares NASDAQ Biotechnology ETF | 1,327,757 | Jul 30, 2019 | 0.51% | 30,219,749 |
| Price (T.Rowe) International Stock Fund | 1,312,291 | Jun 29, 2019 | 0.50% | 27,689,340 |
| American Funds Insurance Ser-International Fund | 793,690 | Jun 29, 2019 | 0.30% | 16,746,859 |
| Allianz Fds-AllianzGI NFJ Mid Cap Value Fd | 651,983 | Mar 30, 2019 | 0.25% | 13,111,378 |
| Smallcap World Fund | 616,400 | Jun 29, 2019 | 0.24% | 13,006,040 |
| AMG Managers Pictet International Fund | 574,386 | Jan 30, 2019 | 0.22% | 10,695,067 |
| Harding, Loevner Funds, Inc-Global Equity Portfolio | 568,498 | Jan 30, 2019 | 0.22% | 10,585,432 |